Alaxan FR Drug Interactions

Ibuprofen, as well as other NSAIDs, co-administered with anticoagulants (eg, warfarin) or thrombolytic agent (eg, streptokinase) may cause bleeding.
Concomitant administration with aspirin decreases ibuprofen blood concentration. Concomitant use of salicylates, phenylbutazone, indomethacin and other NSAIDs could increase the risk of gastrointestinal bleeding.
Ibuprofen, like other NSAIDs, increases plasma or serum levels of lithium resulting to interference with renal elimination of lithium.
Ibuprofen causes acute reduction in renal function and blood pressure response to ACE inhibitors (eg, captopril, enalapril).
Ibuprofen can reduce the natriuretic effect of furosemide and thiazides in some patients which is due to inhibition of renal prostaglandin synthesis.
Paracetamol hepatotoxicity may be increased by drugs which induce the specific microsomal isoenzyme responsible for the metabolic activation of paracetamol. Despite anecdotal reports of such interactions involving ethanol and anticonvulsants, the metabolic activation of paracetamol is not increased in regular heavy drinkers or induced in patients taking phenobarbital or phenytoin. Chronic alcoholics seem to be at particular risk of liver damage following overdosage of paracetamol, but the mechanism is uncertain. Acute ingestion of ethanol markedly reduces the metabolic activation of paracetamol.